Impacto da Infeção e Vacinação SARS-CoV-2 nos Sintomas de Enxaqueca durante a Pandemia COVID-19
DOI:
https://doi.org/10.46531/sinapse/AO/230065/2024Palavras-chave:
COVID-19, Perturbações de Enxaqueca, Vacinas contra COVID-19Resumo
Introdução: Os estudos têm demonstrado agravamento da enxaqueca associado à infeção COVID-19 e à pandemia mais especificamente. A vacinação contra a COVID-19 também tem sido associada a cefaleia sintomática, com elevada frequência nos doentes com enxaqueca. Pretende-se verificar o impacto da COVID-19 na enxaqueca, durante a pandemia por SARS-CoV-2.Métodos: Um questionário online foi enviado para doentes com enxaqueca seguidos na consulta externa de Neurologia, entre março e novembro de 2022. As questões incidiam sobre os sintomas da enxaqueca e alterações do tratamento, assim como alterações do sono, sintomas ansiosos e depressivos durante a pandemia, após o diagnóstico e/ou vacinação da COVID-19.
Resultados: Dos 185 doentes incluídos, 108 (58,4%) reportaram alteração no padrão da cefaleia (intensidade, frequência e/ou tipo de dor) e 47% reportaram aumento da intensidade e frequência. A alteração ocorreu antes do diagnóstico da COVID-19 em 41%. Do total de casos com alteração da cefaleia, 72,2% necessitaram de intensificar a medicação (abortiva ou profilática), independentemente se tiveram infeção. Verificaram-se elevados níveis de insónia e sintomas de ansiedade e depressão nos doentes que agravaram da enxaqueca, independentemente do diagnóstico de COVID-19. Após a vacinação, 49 (27,1%) descreveram uma alteração no padrão da cefaleia, com agravamento em 29 (16%). Em metade, esta alteração ocorreu nas primeiras 3 semanas após a vacinação.
Conclusão: O agravamento da enxaqueca esteve mais provavelmente associado a outros fatores relacionados com a pandemia do que ao diagnóstico de COVID-19. A vacinação pode ter tido um efeito adicional, mas foi um desencadeante menos relevante e temporário.
Downloads
Referências
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. doi: 10.1177/0333102417738202.
Lantéri-Minet M, Radat F, Chautard MH, Lucas C. Anxiety and depression associated with migraine: Influence on migraine subjects’ disability and quality of life, and acute migraine management. Pain. 2005;118319–26.
Sevillano-García MD, Manso-Calderón R, Cacabelos-Pérez P. Comorbilidad en la migraña: depresión, ansiedad, estrés y trastornos del sueño. Rev Neurol. 2007;45:400-5.
Ma M, Fang J, Li C, Bao J, Zhang Y, Chen N, et al. The status and high risk factors of severe psychological distress in migraine patients during nCOV-2019 outbreak in Southwest China: a cross-sectional study. J Headache Pain. 2020;21:100. doi: 10.1186/s10194-020-01168-5.
Holsteen KK, Hittle M, Barad M, Nelson LM. Development and internal validation of a multivariable prediction model for individual episodic migraine attacks based on daily trigger exposures. Headache. 2020;60:2364-79. doi: 10.1111/head.13960.
Moon HJ, Seo JG, Park SP. Perceived stress in patients with migraine: a case-control study. J Headache Pain. 2017;18:73. doi: 10.1186/s10194-017-0780-8.
Suzuki K, Takeshima T, Igarashi H, Imai N, Danno D, Yamamoto T, et al. Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study. J Headache Pain. 2021;22:53. doi: 10.1186/s10194-021-01263-1.
Gentile E, Delussi M, Abagnale C, Caponnetto V, de Cesaris F, Frattale I, et al. Migraine during COVID-19: Data from Second Wave Pandemic in an Italian Cohort. Brain Sci. 2021;11:482. doi: 10.3390/brainsci11040482.
Gonzalez-Martinez A, Planchuelo-Gómez Á, Guerrero ÁL, García-Azorín D, Santos-Lasaosa S, Navarro-Pérez MP, et al. Evaluation of the Impact of the COVID-19 Lockdown in the Clinical Course of Migraine. Pain Med. 2021;22:2079–91. doi: 10.1093/pm/pnaa449.
Verhagen IE, van Casteren DS, de Vries Lentsch S, Terwindt GM. Effect of lockdown during COVID-19 on migraine: A longitudinal cohort study. Cephalalgia. 2021;41:865–70. doi: 10.1177/0333102420981739.
Membrilla JA, Lorenzo Í, Sastre M, Díaz de Terán J. Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross-Sectional Study. Headache. 2020;60:2176-91. doi: 10.1111/head.13967.
Parodi IC, Poeta MG, Assini A, Schirinzi E, del Sette P. Impact of quarantine due to COVID infection on migraine: a survey in Genova, Italy. Neurol Sci. 2020;41:2025-7. doi: 10.1007/s10072-020-04543-x.
Silvestro M, Tessitore A, Tedeschi G, Russo A. Migraine in the Time of COVID-19. Headache. 2020;60:988-9. doi: 10.1111/head.13803.
Schiano di Cola F, Caratozzolo S, di Cesare M, Liberini P, Rao R, Padovani A. Migraine Monitoring in the Time of COVID-19: Triggers and Protectors During a Pandemic. Pain Med. 2021;22:2728–38. doi: 10.1093/pm/pnab202.
Souza DD, Shivde S, Awatare P, Avati A, John SK, Badachi S, et al. Headaches associated with acute SARS-CoV-2 infection: A prospective cross-sectional study. SAGE Open Med. 2021;9:205031212110502. doi: 10.1177/20503121211050227.
Sampaio Rocha-Filho PA. Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management. Headache. 2022;62:650–6. doi: 10.1111/head.14319.
Salamanna F, Veronesi F, Martini L, Landini MP, Fini M. Post-COVID-19 syndrome: the persistent symptoms at the post-viral stage of the disease. a systematic review of the current data. Front Med. 2021;8:653516. doi: 10.3389/fmed.2021.653516.
Ferreira PL, Luzeiro I, Lopes M, Jorge A, Silva B, Ferreira L. Validity and reliability of the Portuguese version of the modified Migraine Disability Assessment. BMC Neurol. 2021;21:58. doi: 10.1186/s12883-021-02085-z.
Gomes AA, Marques DR, Meiavia AM, Cunha F, Clemente V. Psychometric properties and accuracy of the European Portuguese version of the Pittsburgh Sleep Quality Index in clinical and non-clinical samples. Sleep Biol Rhythms. 2018;16:413–22.
Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M. Validation study of a Portuguese version of the Hospital Anxiety and Depression Scale. Psychol Health Med. 2007;12:225–37.
Ailani J, Burch RC, Robbins MS. The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice. Headache. 2022;62:111-2. doi: 10.1111/head.14245.
Bendtsen L, Sacco S, Ashina M, Mitsikostas D, Ahmed F, Pozo-Rosich P, et al. Guideline on the use of onabotulinum-toxinA in chronic migraine: a consensus statement from the European Headache Federation. J Headache Pain. 2018;19:91. doi: 10.1186/s10194-018-0921-8.
Sacco S, Braschinsky M, Ducros A, Lampl C, Little P, van den Brink AM, et al. European headache federation consensus on the definition of resistant and refractory migraine. J Headache Pain. 2020;21:76. doi: 10.1186/s10194-020-01130-5.
Bermejo PE, Dorado R. Zonisamide for Migraine Prophylaxis in Patients Refractory to Topiramate. Clin Neuropharmacol. 2009;32:103–6. doi: 10.1097/WNF.0B013E318170577F.
Al-Hashel JY, Ismail II. Impact of coronavirus disease 2019 (COVID-19) pandemic on patients with migraine: a webbased survey study. J Headache Pain. 2020;21:115. doi: 10.1186/s10194-020-01183-6.
Delussi M, Gentile E, Coppola G, Prudenzano AMP, Rainero I, Sances G, et al. Investigating the Effects of COVID-19 Quarantine in Migraine: An Observational Cross-Sectional Study From the Italian National Headache Registry (RICe). Front Neurol. 2020;11:597881. doi: 10.3389/fneur.2020.597881.
Fernández-de-las-Peñas C, Gómez-Mayordomo V, Cuadrado ML, Palacios-Ceña D, Florencio LL, Guerrero AL, et al. The presence of headache at onset in SARS-CoV-2 infection is associated with long-term post-COVID headache and fatigue: A case-control study. Cephalalgia. 2021;41:1332–41. doi: 10.1177/03331024211020404.
Garcia-Azorin D, Layos-Romero A, Porta-Etessam J, Membrilla JA, Caronna E, Gonzalez-Martinez A, et al. Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients. Cephalalgia. 2022;42:804–9. doi: 10.1177/03331024211068074.
Uygun Ö, Ertas M, Ekizoglu E, Bolay H, Özge A, Kocasoy Orhan E, et al. Headache characteristics in COVID-19 pandemic-a survey study. J Headache Pain. 2020;21:121. doi: 10.1186/s10194-020-01188-1.
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology. 2018;129:343–66. doi: 10.1097/ALN.0000000000002130.
Magdy R, Hussein M, Ragaie C, Abdel-Hamid HM, Khallaf A, Rizk HI, et al. Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study. Cephalalgia. 2020;40:1422–31. doi: 10.1177/0333102420965140.
Cho SJ, Chu MK. Risk factors of chronic daily headache or chronic migraine. Curr Pain Headache Rep. 2015;19:465. doi: 10.1007/s11916-014-0465-9.
Brennan KC, Charles A. Sleep and headache. Semin Neurol. 2009;29:406–18. doi: 10.1055/s-0029-1237113.
Alimoradi Z, Broström A, Tsang HWH, Griffiths MD, Haghayegh S, Ohayon MM, et al. Sleep problems during COVID-19 pandemic and its’ association to psychological distress: A systematic review and meta-analysis. EClinicalMedicine. 2021 Jun;36:100916. doi: 10.1016/j.eclinm.2021.100916.
Kaur RJ, Dutta S, Bhardwaj P, Charan J, Dhingra S, Mitra P, et al. Adverse Events Reported From COVID-19 Vaccine Trials: A Systematic Review. Indian J Clin Biochem. 2021;36:427-39. doi: 10.1007/s12291-021-00968-z.
Sekiguchi K, Watanabe N, Miyazaki N, Ishizuchi K, Iba C, Tagashira Y, et al. Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study. Cephalalgia. 2022;42:266–72. doi: 10.1177/03331024211038654.
Ekizoglu E, Gezegen H, Yalınay Dikmen P, Orhan EK, Ertaş M, Baykan B. The characteristics of COVID-19 vaccine-related headache: Clues gathered from the healthcare personnel in the pandemic. Cephalalgia. 2022;42:366–75. doi: 10.1177/03331024211042390.
Castaldo M, Waliszewska-Prosół M, Koutsokera M, Robotti M, Straburzynski M, Apostolakopoulou L, et al. Headache onset after vaccination against SARS-CoV-2: a systematic literature review and meta-analysis. J Headache Pain. 2022;23:41. doi: 10.1186/s10194-022-01400-4.
Silvestro M, Tessitore A, Orologio I, Sozio P, Napolitano G, Siciliano M, et al. Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine. J Clin Med. 2021;10:5914. doi: 10.3390/jcm10245914.
Göbel CH, Heinze A, Karstedt S, Morscheck M, Tashiro L, Cirkel A, et al. Clinical characteristics of headache after vaccination against COVID-19 (coronavirus SARS-CoV-2) with the BNT162b2 mRNA vaccine: a multicentre observational cohort study. Brain Commun. 2021;3:fcab169. doi: 10.1093/braincomms/fcab169. Erratum in: Brain Commun. 2021;3:fcab195.
Downloads
Publicado
Como Citar
Edição
Secção
Licença
Direitos de Autor (c) 2024 Lénia Silva, Adriana Lopes, Ana Pontes, Ana Gonçalves, Arlinda Chiteculo, Beatriz Soares, Inês Teixeira, Maria Gonçalves, Maria Alves, Maria Cardia, Mariana Monteiro, Raquel Eiras, Sara Costa, Inês Laranjinha, Carlos Andrade, Denis Gabriel
Este trabalho encontra-se publicado com a Creative Commons Atribuição-NãoComercial 4.0.
