Paraparesis Caused by Chronic Lymphocytic Leukemia Mass Compressing the Spinal Cord

Authors

  • Ana João Marques Neurology Department / Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal https://orcid.org/0000-0001-9347-9492
  • Mónica Almeida Pinto Neurology Department / Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
  • Manuel Cunha Hematology Department / Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
  • Ricardo Taipa Neuropathology Department / Centro Hospitalar Universitário do Porto, Porto, Portugal; UMIB - Unidade Multidisciplinar de Investigação Biomédica, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
  • João Paulo Gabriel Neurology Department / Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal

DOI:

https://doi.org/10.46531/sinapse/CC/220053/2022

Keywords:

Leukemia, Lymphocytic, Chronic, B-Cell/complications, Paraparesis/etiology, Spinal Cord Compression/ etiology

Abstract

B-cell chronic lymphocytic leukemia (CLL-B) is the commonest adult-onset leukemia. Although extra-medullary disease has been reported, neurological consequences are seldom a concern. We aim to report an unusual case of a 66 years-old woman who developed subacute paraparesis due to dorsal (D2-D6) spinal cord compression by an extradural CLL mass, 2 years after CLL diagnosis.

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References

Witton LA, Menon S, Perera KS. Central Nervous System Involvement with Chronic Lymphocytic Leukemia. Can J Neurol Sci. 2019;46:640-1. doi: 10.1017/cjn.2019.75.

Strati P, Uhm JH, Kaufmann TJ, Nabhan C, Parikh SA, Hanson CA, et al. Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia. Haematologica. 2016;101:458-65. doi: 10.3324/haematol.2015.136556.

Moazzam AA, Drappatz J, Kim RY, Kesari S. Chronic lymphocytic leukemia with central nervous system involvement: report of two cases with a comprehensive literature review. J Neurooncol. 2012;106:185-200. doi: 10.1007/ s11060-011-0636-z.

Hanse MC, Van’t Veer MB, van Lom K, van den Bent MJ. Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment. J Neurol. 2008;255:828-30. doi: 10.1007/s00415-008-0710-4.

Lopes da Silva R. Spectrum of neurologic complications in chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2012;12:164-79. doi: 10.1016/j.clml.2011.10.005.

Szczepanek D, Wćsik-Szczepanek E, Szymczyk A, Wach M, Cioch M, Podhorecka M, et al. Central nervous involvement by chronic lymphocytic leukaemia. Neurol Neurochir Pol. 2018;52:228-34. doi: 10.1016/j.pjnns.2017.10.012.

Hansen MM. Chronic lymphocytic leukaemia. Clinical studies based on 189 cases followed for a long time. Scand J Haematol Suppl. 1973;18:3-286.

Lustman F, Flament-Durant J, Colle H, Lambert M, Sztern B. Paraplegia due to epidural infiltration in a case of chronic lymphocytic leukemia. J Neurooncol. 1988;6:259-60. doi: 10.1007/BF00163710.

Michalevicz R, Burstein A, Razon N, Reider I, Ilie B. Spinal epidural compression in chronic lymphocytic leukemia. Cancer. 1989;64:1961-4. doi: 10.1002/1097-0142(19891101)64:9<1961::aidcncr2820640932>3.0.co;2-v.

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Published

2024-03-26

How to Cite

1.
Marques AJ, Almeida Pinto M, Cunha M, Taipa R, Gabriel JP. Paraparesis Caused by Chronic Lymphocytic Leukemia Mass Compressing the Spinal Cord. Sinapse [Internet]. 2024 Mar. 26 [cited 2024 Apr. 29];23(1):55-7. Available from: https://sinapse.pt/index.php/journal/article/view/38

Issue

Vol. 23 No. 1 (2023): January - March

Section

Case Reports

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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