Neurolinfomatose Bilateral do Ângulo Ponto-Cerebeloso

Autores

DOI:

https://doi.org/10.46531/sinapse/CC/230056/2023

Palavras-chave:

Ângulo Ponto-Cerebeloso, Linfoma, Neoplasias Cerebelares

Resumo

Os tumores do ângulo ponto-cerebeloso e do canal auditivo interno são frequentes e correspondem, tipicamente, a schwannomas vestibulares (estes, raramente bilaterais) e meningiomas. Descreve-se o caso de um homem de 76 anos que se apresentou com um quadro de paralisia facial periférica persistente, secundária a um processo de neurolinfomatose primária bilateral dos nervos cranianos faciais e vestibulococleares devido a envolvimento sequencial de ambos os ângulos ponto-cerebelosos e canais auditivos internos por linfoma difuso de grandes células B. A neurolinfomatose é uma causa invulgar de lesões com esta topografia. O seu diagnóstico é, habitualmente, difícil e moroso e o prognóstico ominoso. Apesar disso, e em virtude da possibilidade de responder favoravelmente ao tratamento dirigido, se atempado, deve ser considerada aquando do diagnóstico diferencial de tumores do ângulo ponto-cerebeloso em doentes com evolução atípica e agressiva.

Downloads

Não há dados estatísticos.

Referências

- Moffat DA, Ballagh RH. Rare tumours of the cerebellopontine angle. Clin Oncol. 1995;7:28–41.

- Brunori A, Scarano P, Chiappetta F. Non-acoustic neuroma tumor (NANT) of the cerebello-pontine angle: a 15-year experience. J Neurosurg Sci. 1997;41:159–68.

- Markovic N, Ikeda KM. Diffuse Large B-Cell Lymphoma Presenting as Bilateral Internal Auditory Canal Lesions. Can J Neurol Sci. 2017;44:621-3. doi: 10.1017/cjn.2017.23

- Kjolby M, Muller K, Schumacher M. Cerebellopontine angle primary diffuse large B cell (non-Hodgkins) lymphoma mimicking an acoustic schwannoma. Eur J Radiol Extra. 2006;60:93-6.

- Friedmann DR, Grobelny B, Golfinos JG, Roland Jr JT. Nonschwannoma Tumors of the Cerebellopontine Angle. Otolaryngol Clin North Am. 2015;48:461-75. doi: 10.1016/j.otc.2015.02.006.

- Bonneville F, Sarrazin JL, Marsot-Dupuch K, Iffenecker C, Cordoliani YS, Doyon D, et al. Unusual lesions of the cerebellopontine angle: a segmental approach. Radiographics. 2001;21:419-38. doi: 10.1148/radiographics.21.2.g01mr13419.

- Berciano J. Primary central nervous system lymphoma mimicking cerebellopontine angle lesion. Neurologia. 2020;35:506-7. doi: 10.1016/j.nrl.2019.01.002.

- Mori Y, Yamamoto K, Ohno A, Fukunaga M, Nishikawa A. Primary Central Nervous System Lymphoma with Peripheral Nerve Involvement: Case Report. Cureus. 2019;11:e5675. doi: 10.7759/cureus.5675.

- Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neurol Oncol. 2003;5:104–15. doi: 10.1093/neuonc/nop021.

- Tabuchi S, Yoshioka H, Nakayasu, Watanabe T. Primary Central Nervous System Lymphoma of the Cerebellopontine Angle That Initially Occurred as Neurolymphomatosis of the Acoustic Nerve. NMC Case Rep J. 2014;1:28-32. doi: 10.2176/nmccrj.2013-0353.

- Modi T, Verma M, Patkar D. Multiple Cranial Nerve Involvement as a Presentation of Primary Central Nervous System Lymphoma: A Case-Based Review. Asian J Neurosurg. 2021;16:835-40. doi: 10.4103/ajns.AJNS_110_21.

- Singh SS, Mittal BR, Kumar R, Singh H, Balaini N, Goyal M. Primary central nervous system lymphoma with diffuse neurolymphomatosis involving multiple cranial and spinal nerve roots. Clin Nucl Med. 2020;45:e285-e287. doi: 10.1097/RLU.0000000000003018.

- Inoue Y, Hirakawa K, Hayata H, Nishiyama D, Fujino T, Tsukamoto T, et al. Neurolymphomatosis of cranial nerves as the responsible lesions for the vocal cord paralysis and facial nerve palsy in a patient with diffuse large B‐cell lymphoma. Ann Hematol. 2023;102:481-2. doi: 10.1007/s00277-022-05038-9.

- Jayashankar N, Kodur S, Patkar D, Verma M. Primary lymphoma of internal acoustic meatus mimicking vestibular schwannoma-a rare diagnostic dilemma. J Neurol Surg Rep. 2021;82:e1-e5. doi: 10.1055/s-0040-1722343.

- Lin Y, Huang M, Wang F, Xu D, Gao Q, Zang W, et al. Primary large B-cell lymphoma involving the cerebellopontine angle: a case report. Int J Clin Exp Pathol. 2020;13:2612-14.

- Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA. A systematic approach to the diagnosis of suspected central nervous system lymphoma. JAMA Neurol. 2013;70:311. doi: 10.1001/jamaneurol.2013.606.

- Gan HK, Azad A, Cher L, Mitchell PLR. Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol. 2010;12:212-5. doi: 10.1093/neuonc/nop021.

- Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. International Primary CNS Lymphoma Collaborative Group. Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report. Blood. 2010;115:5005-11. doi: 10.1182/blood-2009-12-258210.

- Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl. 2002;549:4–30.

- Danchaivijitr N, Hesselink JR, Aryan HE, Herndier B. Cerebello-Pontine Angle (CPA) Lymphoma With Perineural Extension into the Middle Fossa: Case Report. Surg Neurol. 2004;62:80-5. doi: 10.1016/j.surneu.2003.07.013.

- Blioskas S, Tsaligopoulos M, Kyriafinis G, Psillas G, Markou K, Perifanis V, et al. Bilateral secondary neurolymphomatosis of the internal auditory canal nerves: A case report. Am J Otolaryngol. 2013;34:556-8. doi: 10.1016/j.amjoto.2013.04.002.

- Bromberg JE, Breems DA, Kraan J, Bikker G, van der Holt B, Smitt PS, et al. CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology. 2007;68:1674–9. doi: 10.1212/01.wnl.0000261909.28915.83.

Downloads

Publicado

2023-10-18

Como Citar

1.
Azoia CQ, Marques AJ, Costa A, Taipa R, Rocha L. Neurolinfomatose Bilateral do Ângulo Ponto-Cerebeloso. Sinapse [Internet]. 18 de Outubro de 2023 [citado 11 de Outubro de 2024];23(3):151-6. Disponível em: https://sinapse.pt/index.php/journal/article/view/13

Edição

Secção

Casos Clínicos

Artigos mais lidos do(s) mesmo(s) autor(es)