Acute Cerebellitis or Post-Infectious Cerebellar Ataxia? Approach to Paradigmatic Pediatric Clinical Cases

Authors

  • Beatriz Nunes Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  • Rui Diogo Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0009-0006-6236-7926
  • Mariana Costa Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0003-4501-0192
  • Cristina Pereira Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0009-0000-5895-0242
  • Joana Afonso Ribeiro Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0001-5712-3106
  • Filipe Palavra Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Laboratório de Farmacologia e Terapêutica Experimental, Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal; Centro Académico Clínico de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-2165-130X
  • Fernanda Rodrigues Serviço de Urgência e Unidade de Infeciologia Pediátrica / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-5820-5215
  • Joana Amaral Centro de Desenvolvimento da Criança – Neuropediatria / Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-8892-0551

DOI:

https://doi.org/10.46531/sinapse/CC/230079/2024

Keywords:

Cerebellar Ataxia, Cerebellar Diseases/diagnostic imaging, Child, Encephalitis, Viral, Magnetic Resonance Imaging

Abstract

Acute cerebellitis is a rare disease resulting from dysfunction of the cerebellum or its connections, with infectious or inflammatory causes, varied clinical manifestations, and evidence of predominantly cerebellar inflammation on magnetic resonance imaging (MRI). It belongs to the spectrum of acute post-infectious cerebellar ataxia, a self-limited disease whose therapeutic approach is individualized. Three clinical cases of cerebellar ataxia in pediatric age are described. In case 1, there is a post-infectious context associated with Epstein-Barr virus. In case 2, there is a possible Mycoplasma pneumoniae post-infectious context, with MRI revealing cerebellar inflammation. Steroids were used in both cases. Case 3 presents severe cerebellar post-infection symptoms associated with varicella zoster virus, and human immunoglobulin was given. Evolution was favorable in all. These cases demonstrate the variable spectrum of post-infectious cerebellar ataxia and the different therapeutic options used, depending on the clinical presentation and individual characteristics of affected children.

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References

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Published

2024-04-04

How to Cite

1.
Nunes B, Diogo R, Costa M, Pereira C, Ribeiro JA, Palavra F, et al. Acute Cerebellitis or Post-Infectious Cerebellar Ataxia? Approach to Paradigmatic Pediatric Clinical Cases. Sinapse [Internet]. 2024 Apr. 4 [cited 2024 May 18];24(1):39-44. Available from: https://sinapse.pt/index.php/journal/article/view/46

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Case Reports

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