Radiologically Isolated Syndrome in Pediatric Age: The Ideal Clinical Model for the Study of Remyelination?

Authors

  • Joana Silva Faculdade de Medicina / Universidade de Coimbra, Coimbra, Portugal
  • Ricardo Faustino Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências / Universidade de Lisboa; Escola Superior de Saúde Ribeiro Sanches; Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisboa, Portugal https://orcid.org/0000-0003-2853-0137
  • Filipe Palavra Centro de Desenvolvimento da Criança - Neuropediatria, Hospital Pediátrico; Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR); Centro Clínico e Académico de Coimbra / Centro Hospitalar e Universitário de Coimbra; Universidade de Coimbra, Coimbra, Portugal https://orcid.org/0000-0002-2165-130X

DOI:

https://doi.org/10.46531/sinapse/AR/210032/2022

Keywords:

Child, Magnetic Resonance Imaging, Multiple Sclerosis

Abstract

Radiologically isolated syndrome (RIS) is a condition in which imagiological findings suggestive of demyelination, specifically multiple sclerosis, are seen in neurologically asymptomatic individuals. Hence, RIS is usually referred to as a pre-symptomatic stage of multiple sclerosis, making it an interesting research object, with the goal of modifying the risk of subsequent evolution to that demyelinating disease. RIS can be diagnosed in children and adolescents, but the data available on this condition for this age range is still scarce. This review on pediatric RIS focuses on the benefit of its research, specifically aiming at the eventual development of therapeutic interventions that, in the future, will eventually promote remyelination and neuroprotection.

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References

Okuda DT, Mowry EM, Behestian A, Waubant E, Baranzini SE, Goodin DS, et al. Incidental mri anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome. Neurology. 2009;72:800-5. doi: 10.1212/01. wnl.0000335764.14513.1a.

Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, De Seze J, et al. Radiologically isolated syndrome in children: clinical and radiologic outcomes. Neurol Neuroimmunol NeuroInflamm. 2017;4:e395. doi: 10.1212/ NXI.0000000000000395.

Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, et al. Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Mult Scler J Exp Transl Clin. 2019;5:2055217319836664. doi: 10.1177/2055217319836664.

Neumann B, Segel M, Chalut KJ, Franklin RJM. Remyelination and ageing: reversing the ravages of time. Mult Scler. 2019;25:1835-41. doi: 10.1177/1352458519884006.

Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet Neurol. 2020;19:678-88. doi: 10.1016/S1474-4422(20)30140-X.

McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121-7. doi: 10.1002/ana.1032.

Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005; 58:840-6. doi: 10.1002/ana.20703.

Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292-302. doi: 10.1002/ana.22366.

Filippi M, Rocca MA, Ciccarelli O, de Stefano N, Evangelou N, Kappos L, et al. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol. 2016;15:292-303. doi: 10.1016/S1474-4422(15)00393-2.

Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162-73. doi: 10.1016/S1474-4422(17)30470-2.

Wilbur C, Yeh EA. Radiologically isolated syndrome in children: Current knowledge and future directions. Mult Scler Relat Disord. 2018;24:79-84. doi: 10.1016/j.msard.2018.06.010.

Dangouloff-Ros V, Roux CJ, Boulouis G, Levy R, Nicolas N, Lozach C, et al. Incidental brain MRI findings in children: A systematic review and meta-analysis. Am J Neuroradiol. 2019;40:1818-23. doi: 10.3174/ajnr.A6281.

Jansen PR, Dremmen M, van den Berg A. Incidental Findings on Brain Imaging in the General Pediatric Population. N Engl J Med. 2017;377:1593-5. doi: 10.1056/NEJMc1710724.

Granberg T, Martola J, Kristoffersen-Wiberg M, Aspelin P, Fredrikson S. Radiologically isolated syndrome - Incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler J. 2013;19:271-80. doi: 10.1177/1352458512451943.

Makhani N. The Radiologically Isolated Syndrome: An Opportunity to Prevent Multiple Sclerosis in Children. Pediatr Neurol. 2018;85:13-5. doi: 10.1016/j.pediatrneurol.2018.05.009.

Sellner J, Schirmer L, Hemmer B, Mühlau M. The radiologically isolated syndrome: Take action when the unexpected is uncovered? J Neurol. 2010;257:1602-11. doi: 10.1007/ s00415-010-5601-9.

Makhani N, Tremlett H. The multiple sclerosis prodrome. Nat Rev Neurol. 2021;17:515-21. doi: 10.1038/s41582-021-00519-3.

Tremlett H, Marrie RA. The multiple sclerosis prodrome: Emerging evidence, challenges, and opportunities. Mult Scler. 2021; 27:6-12. doi: 10.1177/1352458520914844.

Yusuf FLA, Ng BC, Wijnands JMA, Kingwell E, Marrie RA, Tremlett H. A systematic review of morbidities suggestive of the multiple sclerosis prodrome. Expert Rev Neurother. 2020; 20:799-819. doi: 10.1080/14737175.2020.1746645.

Makhani N, Lebrun-Frenay C, Siva A, Wassmer E, Narula S, Mar S, et al. Older Age Is Associated with a First Clinical Demyelinating Event in Children with the Radiologically Isolated Syndrome (2671). Neurology. 2020;94:2671.

Carnero-Contentti E, Pettinicchi JP, Caride A, López PA. Decision-making on radiologically isolated syndrome among Argentinean neurologists: A survey based on clinical experience. Mult Scler Relat Disord. 2019;27:61-4. doi: 10.1016/j.msard.2018.09.030.

Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome (OBIT). [consultado Maio 2021] Disponível em: https://clinicaltrials.gov/ct2/ show/NCT03979391

Forster M, Graf J, Mares J, Aktas O, Hartung HP, Kremer D. Drug Treatment of Clinically Isolted Syndrome. CNS Drugs. 2019;33:659-76. doi: 10.1007/s40263-019-00647-x.

de Vries RMV, van Pelt ED, Mescheriakova JY, Wong YYM, Ketelslegers IA, Siepman TAM, et al. Disease course after clinically isolated syndrome in children versus adults: a prospective cohort study. Eur J Neurol. 2017;24:315-21. doi: 10.1111/ene.13196.

Assessment of Tecfidera® in Radiologically Isolated Syndrome (RIS) (ARISE). [consultado Maio 2021] Disponível em: https://clinicaltrials.gov/ct2/show/NCT02739542.

Randomized, Double-blinded Study of Treatment: Teriflunomide in Radiologically Isolated Syndrome (TERIS). [consultado Maio 2021] Disponível em: https://clinicaltrials.gov/ ct2/show/NCT03122652.

Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Semin Neurol. 2020;40:192-200. doi: 10.1055/s-0040-1703000.

Makhani N. Treatment Considerations in the Radiologically Isolated Syndrome. Curr Treat Options Neurol. 2020;22:3. doi: 10.1007/s11940-020-0608-8.

Baaklini CS, Rawji KS, Duncan GJ, Ho MFS, Plemel JR. Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells. Front Mol Neurosci. 2019;12:225. doi: 10.3389/fnmol.2019.00225.

Franklin RJM, Frisén J, Lyons DA. Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin. Semin Cell Dev Biol. 2020;S1084-9521(20)30157-9. doi: 10.1016/j.semcdb.2020.09.009.

Brown RA, Narayanan S, Banwell B, Arnold DL, Canadian Pediatric Demyelinating Disease Network. Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients. Neuroimage Clin. 2014;6:237-42. doi: 10.1016/j. nicl.2014.09.003.

Published

2024-04-20

How to Cite

1.
Silva J, Faustino R, Palavra F. Radiologically Isolated Syndrome in Pediatric Age: The Ideal Clinical Model for the Study of Remyelination?. Sinapse [Internet]. 2024 Apr. 20 [cited 2024 Dec. 4];22(1):16-23. Available from: https://sinapse.pt/index.php/journal/article/view/73

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Review Article

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